I believe so, but I'm not 100% sure as I haven't tried that specific configuration. See this URL and search for "Programmable Knob": https://www.keychron.com/

I believe so, but I'm not 100% sure as I haven't tried that specific configuration. See this URL and search for "Programmable Knob": https://www.keychron.com/products/keychron-q6-qmk-custom-mechanical-keyboard?variant=39990023553113 https://www.keychron.com/products/keychron-q6-qmk-custom-mec... If you go down a bit, you'll see you can program a knob rotation (in one direction or the other) to perform a macro, including key combinations. I'm pretty sure there are also key designations for mouse movements. That said, you might not be able to adjust the granularity of the mouse movement very well (not sure, really).