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Prior to getting into tech, I had an internship at the NY State Psychiatric Institute (NYSPI) where I did work helping people developing assessment tools for sc
by WesternWind 3y ago
Prior to getting into tech, I had an internship at the NY State Psychiatric Institute (NYSPI) where I did work helping people developing assessment tools for schizophrenic prodromes (people before they develop schizophrenia), as they were working on a predictive assessment questionaire.
Basically they were looking for risk factors but also to predict who might actually develop the disease imminently among those at risk, because if you monitor folks at risk, folks who might have subclinical symptoms, and can know who is going to have a psychotic break, you can manage and control it and have much better outcomes.
The largest predictive factor of folks who were at increased risk of developing schizophrenia is if they have a family history of it as I recall. Stress, in a variety of forms, is also a big factor.
However the reason I write is because I remember that late fall and winter conception of the individual has been shown to create a small but statistically significant increase in the likelihood of developing the disease. It's unclear exactly why, but one theory is that increased risk of viral infection for the mother during certain stages of pregnancy may be a factor.
Teasing apart these sort of facotrs, even to the extent possible often requires complex multivariate analysis of general and clinical populations and either time based or retrospective analysis of risk factors. Even then the mechanisms are fairly opaque.
Covid infection may lead to increased understanding of psychotic and subpsychotic disorders, but it's more likely to simply complicate any analysis; just teasing apart the actual effects of the disease and the stress that results from the social changes necessary to contain it, in terms of development of mental illness, may not be fully possible.
- whats_a_quasar 3y agoRelated: "Treating the Prodrome", a discussion about early treatment of schizophrenia and some speculation about possible mechanisms. [1] This sort of work is very exciting to me! Treating schizophrenia early seems like a win for everyone - less of an impact on the individual, less of a need for antipsychotics, and less societal impact. I've also seen some speculation about a prodrome for major depression, with a period characterized by anxiety or agitation before a full episode. Early detection of psychiatric episodes seems like a really ripe approach. [1] https://slatestarcodex.com/2018/09/20/treat-the-prodrome/ https://slatestarcodex.com/2018/09/20/treat-the-prodrome/
- anon84873628 3y agoI believe there was a RadioLab episode that discussed schizophrenia and reduced thermoregulation. Very interesting; it explained why some schizophrenic people wear lots a clothes (a phenomenon one might notice out on the city streets). Could also be used as an early diagnostic tool.
- s0kr8s 3y agoRecent research suggests that schizophrenia may also be immune-mediated or at least immune-system involved. See: https://www.frontiersin.org/articles/10.3389/fpsyt.2022.880568/full https://www.frontiersin.org/articles/10.3389/fpsyt.2022.8805... I was at a psychiatric conference once where the presenter highlighted that the last condition that psychiatry actually "cured" was neurosyphilis, an infection-triggered version of schizophrenia, back in the 1940's.