3 ms·
Autoantibodies were found again Were the antibodies detected, or was their activity detected? Because if it's just about the presence of autoantibodies, the si
by tremon 3y ago
Autoantibodies were found again
Were the antibodies detected, or was their activity detected? Because if it's just about the presence of autoantibodies, the simple explanation may be that aab quantities may not significantly differ, but their activity/activation might.
- xhonk 3y agoAntibodies were detected, not their activity. Here's the assay used: https://www.cell.com/cell-reports-methods/pdf/S2667-2375(22)00024-8.pdf https://www.cell.com/cell-reports-methods/pdf/S2667-2375(22)... Measuring antibody activity is a lot harder than measuring antibodies, just being able to assess antibody targets in a high-throughput manner is a huge and very recent step forward.