The primary difference is rolling vs alternating (as someone else mentioned) and slight left vs right hand biases (I don't think anyone brought this up yet) and

The primary difference is rolling vs alternating (as someone else mentioned) and slight left vs right hand biases (I don't think anyone brought this up yet) and there is some definitely enough room for preference of one over the other there. I prefer rolling over alternating and I'm left-hand dominant. For finger alternation I'd recommend any of the CarpalX layouts (Qgmlwb specifically). If I knew about CarpalX before learning Colemak I probably would have learned it instead but I also don't want to relearn typing for a 4th time. There's always a handful of exceptions to every rule but by and large from my experiences in the altkey layout communities the people who touted Dvorak the loudest largely didn't know how to type properly before learning Dvorak and it was their first alternative layout learned. So it's colored my view a bit. I have regularly typed for >8 hours/day - nearly every day - since age 8. The hand pains didn't really start until I was in my 20's.