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Unfortunately, this study failed to measure cholesterol oxidization. 20 years ago, when this study started, it was still considered bleeding edge science to ev
by DiabloD3 3y ago
Unfortunately, this study failed to measure cholesterol oxidization.
20 years ago, when this study started, it was still considered bleeding edge science to even consider that (or a proxy, particle size), and they recorded all of the wrong values
A quick glance through the paper does not indicate they measured particle size. It also seems they may have measured LDL/HDL/TG fraction, but then did nothing with it (which basically puts this paper at the technological level of the 1950s).
Neither total cholesterol nor LDL/HDL/TG fractions can accurately predict mortality, but particle size can. LDL-P et al tests are quickly becoming the norm as younger doctors enter the field, and their education is more up to date than their older peers.
- nxobject 3y agoAs a complete layperson, it's interesting how eerily intuitive particle size is as a measure of risk: "bigger particles clog up your blood vessels more".
- xenonite 3y agoI understand that the diameter tells whether the LDL is oxidized, which would be bad.
- Try1275 3y agoIt's a shame that it needs younger doctors for things to change if the science and technology is already there.
- the-dude 3y agohttps://en.wikipedia.org/wiki/Planck%27s_principle https://en.wikipedia.org/wiki/Planck%27s_principle
- mfer 3y agoCholesterol tests are common but the better test is to measure APOB. Something that’s not usually covered by insurance and many doctors don’t know about because it’s newer. I noticed heart disease was called out as a co-morbidity to high cholesterol. A lot of cardiovascular disease is caused by excess LDL cholesterol.
- cuchoi 3y agoActually Apo B is a better predictor for cardiovascular risk (and, AFAIK, the actual thing that injuries your arterial wall): "Based on current research, Apolipoprotein B has emerged as the superior marker for assessing cardiovascular disease risk. LDL particle size also has quality evidence behind it, but as it’s a metric that’s not yet as standardized nor as strongly predictive as ApoB, ApoB remains a better assessment of heart health than LDL particle size alone." https://blog.insidetracker.com/impact-ldl-particle-size-apob-heart-health?hs_amp=true https://blog.insidetracker.com/impact-ldl-particle-size-apob... There is a 6 hour lipid series in YouTube where they go into the details: https://youtu.be/5iGl3iPZDis?si=fzL6zmX-iqkF7wF- https://youtu.be/5iGl3iPZDis?si=fzL6zmX-iqkF7wF-
- DiabloD3 3y ago6 hours of a niche science topic? Don't threaten me with a good time.