That comic is about what file types people choose to put what types of information (e.g. PDFs don't often get used for memes, and gifs don't often get used for

That comic is about what file types people choose to put what types of information (e.g. PDFs don't often get used for memes, and gifs don't often get used for scientific research papers). It's not even trying to make a point about the quality of the file formats themselves. (I assume when you wrote "most reassuring" you were instead interpreting it as a comic about the file types' ability to accurately hold the information a user wants them to hold, because "reassuring" as pertains to the comic's actual meaning would be completely irrelevant to this topic of whether or not PDF makes a good interchange format.)