As an anecdotal comparison, over the last year or so, I have lost about 15% of my body weight through diet and exercise, going from 220 down to 190 today. I di

As an anecdotal comparison, over the last year or so, I have lost about 15% of my body weight through diet and exercise, going from 220 down to 190 today. I did this with exercise (walking exclusively for six months, then shifting to walking plus weight training with a coach twice a week). Nothing extreme. I also use a scale that does body mass measurements (consumer grade). It says: 1. My fat-free body weight went from 148.6 down to 143.2. 2. My muscle mass is down from 142 down to 136 (see below) 3. I have had no bone loss of bone mass. As I was walking, I seemed to consistently lose about 25% of the weight in muscle. My weight loss stopped as I started hitting the weights, but I started putting on about a pound per month in muscle, which is very visible on my core and arms. Peter Attia has a nuanced medical take on the drug, based on interactions with his patients (short video https://www.youtube.com/watch?v=T6fhFLv2ERs https://www.youtube.com/watch?v=T6fhFLv2ERs). His take was that the drug works and there are very few side effects. He also uses it as a last resort, as he has seen his patients lose far more bone mass and muscle than he would like. However, it is a lifesaver for people who don't have success with other methods. Personally, I don't want to use it, but don't judge others for making the right medical decisions for themselves.