4 ms·
The high prevalence of CF in the white population was hypothesized to be due to the protective effect of being a carrier (heterozygous) of a CFTR mutation again
by car 3y ago
The high prevalence of CF in the white population was hypothesized to be due to the protective effect of being a carrier (heterozygous) of a CFTR mutation against typhoid fever, very common in Europe in the old ages.
A study in 1997 was able to prove this [0].
[0] https://pubmed.ncbi.nlm.nih.gov/9590693/ https://pubmed.ncbi.nlm.nih.gov/9590693/
- bdcravens 3y agoCholera as well.
- car 3y agoThank you! I forgot about that. This was researched as early as 1994 [0] [0] "Cystic fibrosis heterozygote resistance to cholera toxin in the cystic fibrosis mouse model", https://pubmed.ncbi.nlm.nih.gov/7524148/ https://pubmed.ncbi.nlm.nih.gov/7524148/
- tastyfreeze 3y agoInteresting. Similar story with sickle cell anemia, more common in Africa, and malaria.
- 0600-885310 3y ago[flagged]