4 ms·

Here's a 2019 article, "Study suggests how measles depletes body’s immune memory"[0] which (despite the title) seems to quantify the percentage of antibody arse

Here's a 2019 article, "Study suggests how measles depletes body’s immune memory"[0] which (despite the title) seems to quantify the percentage of antibody arsenal that is lost after a measles infection. Sadly, I haven't had luck finding resources to answer "by what mechanism does measles cause antibody memory to be lost?", but I've got a good thing to ponder for the weekend. Thanks. :) [0] https://news.harvard.edu/gazette/story/2019/10/how-measles-wipes-out-the-bodys-immune-memory/ https://news.harvard.edu/gazette/story/2019/10/how-measles-w...

pazimzadeh 3y ago
Also, HIV depletes your T cells
- ianlevesque 3y ago
  And SARS-CoV-2, unfortunately.
  - ekianjo 3y ago
    ?? 99.9% of people recover just fine and surely they still have their T cells
    - ianlevesque 3y ago
      It’s probably a waste of breath on this forum at this point, but look it up, and how long it takes even HIV infected individuals to become clinically immunodeficient.
    - forgetfreeman 3y ago
      How confident are you in your position? Literally 30 seconds spent searching: https://www.nature.com/articles/s41418-022-00936-x https://www.nature.com/articles/s41418-022-00936-x
      - Shugarl 3y ago
        I've only skimmed it, but doesn't the article you linked indicate that it is only true for severe/ life-threatening cases of COVID-19?
        deleted 3y ago
        [deleted]
        forgetfreeman 3y ago
        Doesn't matter, it shows that covid can deplete t-cells as claimed up-thread.
        ekianjo 3y ago
        extreme cases of covid is not relevant for 99.9% of people so that's sufficiently close enough to say your claim is exaggerated. Sure, colds can kill too, but we don't treat them the same as Ebola.
        forgetfreeman 3y ago
        The claim that a thing happens is not invalidated by it's relative frequency. You don't get to pretend lightning doesn't exist despite the relative rarity of people being hit by it.
Izkata 3y ago
Here you go: https://asm.org/Articles/2019/May/Measles-and-Immune-Amnesia https://asm.org/Articles/2019/May/Measles-and-Immune-Amnesia Very short version: it infects the tissue that create the cells that contain or immune memory, replacing them with versions that only know about the measles virus. Sounds like it's not permanent, though the article doesn't make it clear whether it's recovery or re-learning.
- simondotau 3y ago
  Our immune system is quite aggressive with garbage collection and can picky about what pathogens it chooses to remember. This behaviour makes sense on the hypothesis that our immune system has a "storage limit" for immunities. It doesn't make sense if the immunity memory is unlimited. (The reason why many vaccines require boosters is that without the repeat exposure, our immune system decides it doesn't need to remember about that particular pathogen.)

pazimzadeh 3y ago

Also, HIV depletes your T cells

ianlevesque 3y ago
And SARS-CoV-2, unfortunately.
- ekianjo 3y ago
  ?? 99.9% of people recover just fine and surely they still have their T cells
  - ianlevesque 3y ago
    It’s probably a waste of breath on this forum at this point, but look it up, and how long it takes even HIV infected individuals to become clinically immunodeficient.
  - forgetfreeman 3y ago
    How confident are you in your position? Literally 30 seconds spent searching: https://www.nature.com/articles/s41418-022-00936-x https://www.nature.com/articles/s41418-022-00936-x
    - Shugarl 3y ago
      I've only skimmed it, but doesn't the article you linked indicate that it is only true for severe/ life-threatening cases of COVID-19?
      - deleted 3y ago
        [deleted]
      - forgetfreeman 3y ago
        Doesn't matter, it shows that covid can deplete t-cells as claimed up-thread.
        ekianjo 3y ago
        extreme cases of covid is not relevant for 99.9% of people so that's sufficiently close enough to say your claim is exaggerated. Sure, colds can kill too, but we don't treat them the same as Ebola.
        forgetfreeman 3y ago
        The claim that a thing happens is not invalidated by it's relative frequency. You don't get to pretend lightning doesn't exist despite the relative rarity of people being hit by it.

Izkata 3y ago

Here you go: https://asm.org/Articles/2019/May/Measles-and-Immune-Amnesia https://asm.org/Articles/2019/May/Measles-and-Immune-Amnesia Very short version: it infects the tissue that create the cells that contain or immune memory, replacing them with versions that only know about the measles virus. Sounds like it's not permanent, though the article doesn't make it clear whether it's recovery or re-learning.

simondotau 3y ago
Our immune system is quite aggressive with garbage collection and can picky about what pathogens it chooses to remember. This behaviour makes sense on the hypothesis that our immune system has a "storage limit" for immunities. It doesn't make sense if the immunity memory is unlimited. (The reason why many vaccines require boosters is that without the repeat exposure, our immune system decides it doesn't need to remember about that particular pathogen.)