> [...] human brain cells were transplanted into the brains of genetically modified mice. The discovery is that MEG3 is the molecule that is expressed when amy

> [...] human brain cells were transplanted into the brains of genetically modified mice. The discovery is that MEG3 is the molecule that is expressed when amyloid plaques form. It signals the neurons to kill themselves. Here's the paper: MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease https://www.science.org/doi/10.1126/science.abp9556 https://www.science.org/doi/10.1126/science.abp9556 > The human neurons, but not the mouse neurons, displayed severe Alzheimer’s pathology, including tangles and necroptosis. Human neurons up-regulated the neuron-specific maternally expressed gene 3 (MEG3) in response to amyloid plaques.