It's missing a lot of context. > The mouse that eats less but gains weight > Unexpectedly, this increased adiposity is not caused by increased food intake. In

It's missing a lot of context. > The mouse that eats less but gains weight > Unexpectedly, this increased adiposity is not caused by increased food intake. Instead, Mc3r-/- mice gain more fat per calorie of food consumed, apparently at the expense of their lean body mass. This so-called increased feed efficiency means that the mutant mice store more fat despite eating less than normal mice do, and they become obese if fed a high-fat diet. The mechanism behind these responses is unclear because the Mc3r-/- mice have normal metabolic rates, body temperatures, and thyroid function https://www.ncbi.nlm.nih.gov/books/NBK2330/ https://www.ncbi.nlm.nih.gov/books/NBK2330/ Also a lot of counterpoints in this article. https://slimemoldtimemold.com/2021/07/11/a-chemical-hunger-part-ii-current-theories-of-obesity-are-inadequate/ https://slimemoldtimemold.com/2021/07/11/a-chemical-hunger-p... E.g. > consider Poehlman et al. (1986), where researchers fed a group of 12 men 1,000 extra calories a day for 22 days. On average the men gained about 5 lbs (2.2 kg), but some of them actually lost weight instead. ... > The fact that many of these are twin studies provides even more evidence against CICO. In groups of twins that are all overfed by the same amount, there is substantial variation between the different participants in general. Some people gain a lot of weight, others gain almost none. But each person gains (or loses!) about the same amount of weight as their twin. In some cases these correlations can be substantial, as high as r = 0.90. This strongly suggests that genetics plays a large role in determining how the body responds to overfeeding.