This example is technically correct, but not appropriate. Since we are comparing pain to depression, the comparison should be for chronic pain not acute pain. O

This example is technically correct, but not appropriate. Since we are comparing pain to depression, the comparison should be for chronic pain not acute pain. Otherwise we would also be talking about curing grief and sadness with neurotransmitters, which clearly isn't a thing. Getting a nail stuck through your foot is more like a close friend or relative dying. Having chronic pain is more like having depression (well, that and chronic pain very often leads to depression, and the reduction in opioid receptor availability may be somehow related, but that's a whole other thing). The parent comment's point about opioid receptors becoming less available in chronic pain (and the linked article pointing out that opioids are generally terrible for dealing with chronic pain) is quite relevant here. Opioids kind of work at first for chronic pain, but they progressively work less and less and have increasingly negative side effects over time. There are certainly some parallels with many people's experience with some neurotransmitter targeting meds. None of this means that GP is necessarily wrong about their assertions regarding SSRI and similar medications, but it is worth stopping to consider the possibility at least.