3 ms·
Phenylephrine is ineffective when taken orally. It is super effective topically or iv. I can definitely tell, because it's the most commonly used vasopressor us
by rscho 3y ago
Phenylephrine is ineffective when taken orally. It is super effective topically or iv. I can definitely tell, because it's the most commonly used vasopressor used under anaesthesia (iv). Also used topically to avoid nosebleeds during nasal intubation.
- tech_ken 3y agoCurious about how this aligns with the bioavailability point discussed in the article. Presumably if the gut lining is where the bulk of metabolism occurs then IV sidesteps this and increase the bioavail drug, leading to improved efficacy.
- wrs 3y agoThe gut metabolism makes it less available, which is why if you put it in your stomach not much shows up in your nasal lining. If you spray it or inject it directly where it needs to go, no problem.
- Tao3300 3y agoI was indeed surprised to see it go by in the mix during one of my wife's c-sections. I'd always thought it was a completely useless thing, but there it was keeping her blood pressure stable under the anesthetics.