> If you get exposed to a lot of glucocorticoids, you're more at risk now for depression. You can see this epidemiologically: you get people, and statistically,

> If you get exposed to a lot of glucocorticoids, you're more at risk now for depression. You can see this epidemiologically: you get people, and statistically, before their first major depressive episode something awful stressful occurs. Have one of those first depressive episodes, due to some stressful event, you come out the other side eventually. You are no more at risk for depression than anybody else. Along comes a second major stressor, and you fall into depression, come out the other end, no more at risk than anyone else for depression. Somewhere around the fourth or fifth stress-induced depression, something happens and things start cycling on their own there and you no longer need a major stressor to cause you to get depressed like that. That's when the clocks are off and running. That's the transition.[0] 0. Dr. Robert Sapolsky, PhD, 2009 - https://youtu.be/NOAgplgTxfc?t=2165&si=P0pg-W5lOe3n0LWb https://youtu.be/NOAgplgTxfc?t=2165&si=P0pg-W5lOe3n0LWb