3 ms·
there is something odd about their results. the compound was found not to be effective at either 0.1x or 10x of the effective dose. and they don't really explai
by xk_id 3y ago
there is something odd about their results. the compound was found not to be effective at either 0.1x or 10x of the effective dose. and they don't really explain why. this kind of dose-response curve makes it impractical to use.
- kens 3y agoWow, you're right; the results are very strange. Concentrations of 50, 5, and .05 have no effect at all, while .5 almost completely eliminated biofilm. That kind of looks like experimental error. Figure 1 at https://www.mdpi.com/2079-6382/12/6/1017 https://www.mdpi.com/2079-6382/12/6/1017
- arcticfox 3y agoWowwwww. I desperately want this approach to hold up but who in their right mind puts that in a paper with only the caveat “interestingly, only one dose worked.” when they tested three others with literally zero effect and there’s no known mechanistic reason listed. I hope I’m missing something but that looks like a ridiculous blunder perhaps made to get forward to publishing.
- ta988 3y agoUnfortunately typical of compounds that have promiscuous activities. Lets wait for this to be replicated or applied before getting excited.