4 ms·
That's unfortunately not the case. Yes, mRNA based meds had been going through proper testing. They kept failing due to severe safety problems that only appear
by nvm0n2 3y ago
That's unfortunately not the case.
Yes, mRNA based meds had been going through proper testing. They kept failing due to severe safety problems that only appeared after multiple doses.
https://www.statnews.com/2017/01/10/moderna-trouble-mrna/ https://www.statnews.com/2017/01/10/moderna-trouble-mrna/
It never proved safe enough to test in humans, according to several former Moderna employees and collaborators who worked closely on the project
mRNA is a tricky technology. Several major pharmaceutical companies have tried and abandoned the idea, struggling to get mRNA into cells without triggering nasty side effects.
The problems were big enough that Moderna was being written up as an impending car crash. As recently as 2017 their drugs weren't safe enough to deploy in humans because the body reacted badly after being exposed to multiple doses.
So what did they do? Well, unfortunately for us, they didn't know how to solve the safety problems and gave up. Instead they switched from drug development to vaccine development, and why did they do that?
The indefinite delay on the Crigler-Najjar project signals persistent and troubling safety concerns for any mRNA treatment that needs to be delivered in multiple doses, covering almost everything that isn’t a vaccine, former employees and collaborators said.
Oh dear. Safe only if you don't take it more than once.
The reason no further mRNA tech has come to market since isn't because the pandemic made the same things happen faster. It's because the problems with mRNA drugs were never actually solved. The pandemic obliterated all standards and safety mechanisms, creating a mass hysteria that steamrollered any objections in its path. Now the hysteria has faded, the problems are reasserting themselves.