Yes [1]: > This consisted of transferring to healthy people small amounts of material from smallpox sores, resulting in milder forms of illness and much lower

Yes [1]: > This consisted of transferring to healthy people small amounts of material from smallpox sores, resulting in milder forms of illness and much lower mortality than natural infection. Some sources suggest practices of variolation were taking place as early as 200 BCE. [1] https://www.who.int/news-room/spotlight/history-of-vaccination/history-of-smallpox-vaccination https://www.who.int/news-room/spotlight/history-of-vaccinati... It’s a bit disappointing your comment was disliked. It’s on topic and completely relevant.