5 ms·

it can only be thru infection not vaccination?

by uwagar 3y ago

Terr_ 3y ago
It's very possible, because the two scenarios play out rather differently: In a real infection, most spike proteins are assembled into very small viral particles which leave the cell to find new victims. (In the case of SARS-Cov-2, it's a continuous process, some other viruses swell up into one massive cell-explosion.) If it's an mRNA vaccination, cells create spike proteins and hang them to their cell membranes in an orderly fashion. This makes it easy for your immune system to systematically gobble them up as large units and burn the spike proteins (and the rest of the untrustworthy cell) away. Also, it's a much smaller number of your cells, and most are in a pretty safely boring place like the muscle of your arm.
- uwagar 3y ago
  however, blood clots where one of the side effects of the astrazeneca vaccine, not sure about the mRNA vaccines. this prompted my OP.
  - Terr_ 3y ago
    IANACellularBiologist, but while that vaccine doesn't use mRNA (it uses a crippled version of another virus) the goal is still to get some cells calmly exposing spike proteins on its outer membrane... so I'd still group it together in the "should be easier for your body to find and dispose of the spike proteins" category.
  - scotty79 3y ago
    It was due to use of specific adenovirus shell. Some people have some weird antibodies that in some cases might cause clotting problems because of the interaction with adenovirus shell. Just a bad luck that has nothing to do with coronavirus spike proteins. So mRNA vaccines don't suffer from the same problem.
    - uwagar 3y ago
      15% seems high
      - scotty79 3y ago
        Because it's a high, made up number. Actual incidence of blood clotting induced by adenovirus vaccine is closer to one in 100000.
        uwagar 3y ago
        if the article contains made-up things one wonders if the article itself is made-up.
        scotty79 3y ago
        Oh, sorry, I mistook 15% as the number referring to clotting issues caused by astra zeneca vaccine. If it refers to post covid clotting issues and long covid in general it may very well be accurate.

it can only be thru infection not vaccination?

by uwagar 3y ago

it can only be thru infection not vaccination?

It's very possible, because the two scenarios play out rather differently: In a real infection, most spike proteins are assembled into very small viral particles which leave the cell to find new victims. (In the case of SARS-Cov-2, it's a continuous process, some other viruses swell up into one massive cell-explosion.) If it's an mRNA vaccination, cells create spike proteins and hang them to their cell membranes in an orderly fashion. This makes it easy for your immune system to systematically gobble them up as large units and burn the spike proteins (and the rest of the untrustworthy cell) away. Also, it's a much smaller number of your cells, and most are in a pretty safely boring place like the muscle of your arm.

uwagar 3y ago
however, blood clots where one of the side effects of the astrazeneca vaccine, not sure about the mRNA vaccines. this prompted my OP.
- Terr_ 3y ago
  IANACellularBiologist, but while that vaccine doesn't use mRNA (it uses a crippled version of another virus) the goal is still to get some cells calmly exposing spike proteins on its outer membrane... so I'd still group it together in the "should be easier for your body to find and dispose of the spike proteins" category.
- scotty79 3y ago
  It was due to use of specific adenovirus shell. Some people have some weird antibodies that in some cases might cause clotting problems because of the interaction with adenovirus shell. Just a bad luck that has nothing to do with coronavirus spike proteins. So mRNA vaccines don't suffer from the same problem.
  - uwagar 3y ago
    15% seems high
    - scotty79 3y ago
      Because it's a high, made up number. Actual incidence of blood clotting induced by adenovirus vaccine is closer to one in 100000.
      - uwagar 3y ago
        if the article contains made-up things one wonders if the article itself is made-up.
        scotty79 3y ago
        Oh, sorry, I mistook 15% as the number referring to clotting issues caused by astra zeneca vaccine. If it refers to post covid clotting issues and long covid in general it may very well be accurate.