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It sounds like a really bad idea for a Stage IV cancer patient to fast. In later stages they frequently already have substantial weight loss... and in the last

It sounds like a really bad idea for a Stage IV cancer patient to fast. In later stages they frequently already have substantial weight loss... and in the last few weeks, people actually stop eating entirely as the body starts to shutdown. Death usually occurs when the weight loss reaches 30-40%. Encouraging them to stop eating seems like it would just accelerate death. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114624/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114624/

jsperx 3y ago
I just went through 6 cycles of 5-day IV chemotherapy (AIM) and I fasted for all of them, for a total of over 35 days of water-only fasting during the last 5 months. I can’t find the PubMed link right now but there were small studies that looked like healthy cells would go into kind of a suspend/preserve mode that lessened side effects, whereas cancer cells still experienced the intended cytotoxicity. I tolerated the treatments quite well, lost hair of course but only vomited twice during the whole time. Lost weight each time but was able to put it back on quickly during the following week for each cycle, though I do want to watch body composition (don’t want to trade muscle for fat). Did it make a difference in effectiveness? I actually have my follow up scans tomorrow to find out. As you can imagine, I really really hope so. https://news.usc.edu/29428/fasting-weakens-cancer-in-mice/ https://news.usc.edu/29428/fasting-weakens-cancer-in-mice/
- rgbrenner 3y ago
  I'm not a doctor. Ive just spent a lot of time looking into this (as im sure you have) because a close relative died from Stage IV lung cancer. There are studies on fasting with chemo.. and depending on the type of cancer its either effective or ineffective. My comment was specifically about the end stages where cachexia is common (from my link above): "Cachexia is associated particularly with cancer where the prevalence can reach 50–80% in advanced malignant cancer." And all of the advice Ive found says fasting is not recommended for patients with cachexia. It sounds like it was fine in your case though because you were able to regain the weight. Best of luck with your scans.
- bluecheese452 3y ago
  Good luck!
- drunkenmagician 3y ago
  All the best - Cancer sucks!
- krashidov 3y ago
  Best of luck to you!
chasil 3y ago
There have been studies that p53 can be reactivated by fasting. In the context of chemotherapy, couldn't that be a quantitatively useful benefit? "Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism" https://pubmed.ncbi.nlm.nih.gov/35061544/ https://pubmed.ncbi.nlm.nih.gov/35061544/
- ggfdyjgfth4455 3y ago
  I am not a doctor. It is very sunny in the middle east (skin cancer?). Fasting is part of their cultural/religious tradition.
  - chasil 3y ago
    Sorry that you were down voted. I did upvote you.
ambicapter 3y ago
In the book he recommends against in cases of muscle wasting (cachexia), yes.

jsperx 3y ago

I just went through 6 cycles of 5-day IV chemotherapy (AIM) and I fasted for all of them, for a total of over 35 days of water-only fasting during the last 5 months. I can’t find the PubMed link right now but there were small studies that looked like healthy cells would go into kind of a suspend/preserve mode that lessened side effects, whereas cancer cells still experienced the intended cytotoxicity. I tolerated the treatments quite well, lost hair of course but only vomited twice during the whole time. Lost weight each time but was able to put it back on quickly during the following week for each cycle, though I do want to watch body composition (don’t want to trade muscle for fat). Did it make a difference in effectiveness? I actually have my follow up scans tomorrow to find out. As you can imagine, I really really hope so. https://news.usc.edu/29428/fasting-weakens-cancer-in-mice/ https://news.usc.edu/29428/fasting-weakens-cancer-in-mice/

rgbrenner 3y ago
I'm not a doctor. Ive just spent a lot of time looking into this (as im sure you have) because a close relative died from Stage IV lung cancer. There are studies on fasting with chemo.. and depending on the type of cancer its either effective or ineffective. My comment was specifically about the end stages where cachexia is common (from my link above): "Cachexia is associated particularly with cancer where the prevalence can reach 50–80% in advanced malignant cancer." And all of the advice Ive found says fasting is not recommended for patients with cachexia. It sounds like it was fine in your case though because you were able to regain the weight. Best of luck with your scans.
bluecheese452 3y ago
Good luck!
drunkenmagician 3y ago
All the best - Cancer sucks!
krashidov 3y ago
Best of luck to you!

chasil 3y ago

There have been studies that p53 can be reactivated by fasting. In the context of chemotherapy, couldn't that be a quantitatively useful benefit? "Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism" https://pubmed.ncbi.nlm.nih.gov/35061544/ https://pubmed.ncbi.nlm.nih.gov/35061544/

ggfdyjgfth4455 3y ago
I am not a doctor. It is very sunny in the middle east (skin cancer?). Fasting is part of their cultural/religious tradition.
- chasil 3y ago
  Sorry that you were down voted. I did upvote you.

ambicapter 3y ago

In the book he recommends against in cases of muscle wasting (cachexia), yes.