Dude, the only important difference is the interaction cross section, in practice virtually all particle detections happen via secondary effects: for example CC

Dude, the only important difference is the interaction cross section, in practice virtually all particle detections happen via secondary effects: for example CCD chips also observe the secondary interaction effect (of a electron being kicked out), and with gamma ray detectors you often don't see the entire secondary effect because the photon exists the detector before being fully absorbed.