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And in fact the two linages only different by 2 bases, something that can occur in a single host, it in no way indicates there were two jumps. All you need is f
by baja_blast 3y ago
And in fact the two linages only different by 2 bases, something that can occur in a single host, it in no way indicates there were two jumps. All you need is for a virus to be circulating in humans for like a week.
As Stanford Biologist Michael Lim points out:
>indeed he goes straight from seeing 2 lineages to concluding there were 2 jumps from wildlife days apart. That : (a) assumes the jumps were from wildlife, not people. (b) hides the fact that >2 mutations are being made in each host anyway, so separate events not needed
https://twitter.com/michaelzlin/status/1632249640832880640 https://twitter.com/michaelzlin/status/1632249640832880640
>Indeed Worobey seems to think "Lineage A" and "Lineage B" are some profoundly different lineages but the tree he shows confirms they are different by only 2 bases. The "A" root has 2 fewer mutations than the "B" root. He doesn't point this out. Yet he must know.
https://twitter.com/michaelzlin/status/1632249637645201408 https://twitter.com/michaelzlin/status/1632249637645201408
- pcrh 3y agoIt isn't the fact that there are two mutations that defines two lineages. One lineage is different from the other at two positions. The mutations defining these two lineages could have occurred in either animals or humans. What it does imply is that SARS-CoV2 was circulating at the Wuhan market for at least weeks or months before the first samples were collected. However, two base changes is very little data from which to construct a phylogenetic relationship or make "molecular clock" calculations.