3 ms·
if you go over the maths on the shotgun method, not taking into account systematic difficulty in sequencing (like tandem repeats), the likelihood of incomplete
by throwawaymaths 3y ago
if you go over the maths on the shotgun method, not taking into account systematic difficulty in sequencing (like tandem repeats), the likelihood of incomplete coverage vanishes much more rapidly than you'd expect, and after about 5-10x coverage volume, coverage is basically linear in the total amount of sequencing.