6 ms·
Training immune cells to remove ‘trash’ helps resolve lung inflammation
- justinclift 3y agoIt's another "in mice only so far" one.
- okonomiyaki3000 3y ago[flagged]
- apsec112 3y agoIN MICE
- okonomiyaki3000 3y ago[flagged]
- _9za9 3y agoDoes going for a long distance run also remove trash?
- Modified3019 3y agoI imagine that would depend on air quality/pollution. I believe there have been studies on running vs exposure to better and worse environments.
- pazimzadeh 3y agoProbably induces small amounts of tissue damage that stimulates repair pathways, yeah
- gabereiser 3y agoNot unless you’ve got a garbage bag. Running is good though but don’t think that heavy breathing is expelling any particulates faster than you inhale them. It can definitely create inflammation which can stimulate growth. Just as micro tears of muscle tissue during exercise increases muscle density and strength. Run. Just don’t think to yourself you’re undoing anything. Think of it as extending. I wish I had the endurance to join you.
- DoreenMichele 3y agoAbsolutely. https://news.ycombinator.com/item?id=25427090 https://news.ycombinator.com/item?id=25427090
- ck2 3y agoIt is an interesting study in mice but so oddly specific that I wonder why it's on HN? But saving lungs is important because alveolar regeneration is currently an impossible technological fantasy and most lung transplant patients die after a few years from organ rejection. All those transplant stories you heard in 2020 from the alpha/beta forms of covid destroying lungs are either gone now or on their way (or looking at another transplant) There's still no cure for ARDS/COPD which is a slow death sentence but during my post-covid research when I thought I had permanent severe lung damage I found this one Professor "Robert Stockley" at University Hospital Birmingham who has been testing various things since the 1990s like Vitamin A derivatives (Retinoids) to reverse lung damage. He's found things that work in animals but not humans. https://www.birmingham.ac.uk/birmingham-in-action/news/donor-robert-stockley-is-funding-phd-students-copd-research.aspx https://www.birmingham.ac.uk/birmingham-in-action/news/donor... adding: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188766/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188766/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188766/table/tbl2/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188766/table/t...
- pazimzadeh 3y agoAt a very high level, I am very interested in the general concept that sometimes, the same thing that causes you a problem can be the solution to the problem. Examples I have come up with so far: 1. radiation: causes cancer, but preferentially kills cancer cells 2. glue: sticks, but can be used to dissolve old glue to separate stuck things 3. violence: threat of mutually assured destruction can lead to peace, theoretical 4. infection: stimulates your immune system against further infection 5. ???
- CameronNemo 3y agoI believe that the concept is called Hormesis. https://en.m.wikipedia.org/wiki/Hormesis https://en.m.wikipedia.org/wiki/Hormesis
- pazimzadeh 3y agoKind of, but not precisely? Hormesis is that idea that the same compound can have opposite effect at different doses. But a dose difference is not strictly necessary for what I am talking about
- Terr_ 3y agoSill not what you're looking for, but another term to throw in the bag: "Iatrogenic" A disease or problem which is a side-effects of medical investigation or treatment.
- petrocrat 3y agoThe term for the parent comment's concept is anti-fragile
- DoreenMichele 3y agoHomeopathy is an alternative medicine based on the theory of treating ‘like with like’. https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/homeopathy https://www.betterhealth.vic.gov.au/health/conditionsandtrea... For the record, I am not a practitioner of homeopathy. I just know from talking to people that this is the idea behind it.
- dghughes 3y agoLung inflammation is a terrible thing and not to be dismissed. My Dad had scarring of his lung tissue cause unknown it's called idiopathic pulmonary fibrosis. Some thing or inflammation damaged his lungs I don't think and I hope it wasn't genetic but there familial part to it. I could tell by the sound of his breathing ten years before he was officially diagnosed that something was wrong I thought his heart due to family history but hindsight is 20/20. I'm the same age now as when he first started sounding bad when he was breathing. His father my grandfather died of emphysema not sure if related since my grandfather was a smoker. My Dad's doctor said cancer would be easier to treat. Dad made it another ten years past a diagnosis of three years he was given to live but he lived in dread all that time. What really got him in the end was anxiety not so much the disease.
- 01100011 3y agoYeah, I knew someone with idiopathic pulmonary fibrosis. Came out of nowhere and in a couple short years they needed a lung transplant. No explanation, no cure, in an otherwise healthy person.
- eru 3y agoAs an aside: when modern medicine puts 'idiopathic' in front of any condition it means that the doctors don't know what's going on (yet). https://en.wikipedia.org/wiki/Idiopathic_disease https://en.wikipedia.org/wiki/Idiopathic_disease
- presidentender 3y agoMy mom died of idiopathic pulmonary fibrosis resulting from "interstitial lung disease," which is a nasty progressive feedback loop of inflammation, scarring, and reduced lung volume. She'd cough, which would make small tears, which would scar, which would mean there was less working lung around later. Her lifestyle was a contributing factor. She didn't smoke but her house was full of pet dander and she used a wood stove. I do have the exercise-induced reactive airway thing to which she attributed her frailty early on, so maybe I'll go the same way.
- DoreenMichele 3y agoGenerally speaking, this is how the immune system works. We get exposed to a thing the first time, our body doesn't know what to do about it, figures it out and future infections with the same thing are typically handled more effectively. It's the principle behind vaccines.
- 1letterunixname 3y agoSince we've evolved with famine, rather than excess, over millions of years, calorie restriction (not malnutrition) probably couldn't hurt.