Google Scholar shows this article cited by 2040, so quite a lot of attention. Scanning through the literature, the question in the title doesn't seem to have be

Google Scholar shows this article cited by 2040, so quite a lot of attention. Scanning through the literature, the question in the title doesn't seem to have been answered to everone's satisfaction. The original article is online: https://www.nejm.org/doi/full/10.1056/NEJM200105243442106 https://www.nejm.org/doi/full/10.1056/NEJM200105243442106 Some letters to the editor about it: https://math.dartmouth.edu/~doyle/docs/40/letters.pdf https://math.dartmouth.edu/~doyle/docs/40/letters.pdf