3 ms·

It functionally is. Aging is just the build-up of error in genes as microscopic write errors accumulate in successive cell epochs. It is, in short, a degenerat

It functionally is. Aging is just the build-up of error in genes as microscopic write errors accumulate in successive cell epochs. It is, in short, a degenerative process marked by the failure to perfectly maintain instruction sets for the creation and maintenance of structures that allowed for survival. Reading that back it almost sounds political.

inglor_cz 3y ago
"Aging is just the acclimation of error in genes as microscopic write errors accumulate in successive cell epochs." I don't think there is a scientific consensus on this particular mechanism as a root of aging. There is a lot of stuff happening along like epigenetic aging, accumulation of various toxins and seemingly pre-programmed atrophy of immune system in mammals. The only de-aging experiment that demonstrated some positive results in humans didn't touch genes at all. It was the TRIIM and TRIIM-X trial which attempted to rejuvenate the thymus and thus reinvigorate immunity. The subjects exhibit a lot of changes consistent with being a bit younger (a few years).
- RelativeDelta 3y ago
  I am unfamiliar with "epigenetic aging". Are you talking about methylation causing worse performance in one arena or another? Immune atrophy and toxic accumulation I would read as being the terminal effects of decreased functionality as a result of error accumulation, no?
  - inglor_cz 3y ago
    The following page is written in a reasonably readable prose and lists all the currently accepted hallmarks of aging. Genomic instability is on the list, but many other things beside it. https://www.lifespan.io/topic/why-we-age/ https://www.lifespan.io/topic/why-we-age/ But there has been recent talk about adding five more: https://www.lifespan.io/news/researchers-propose-five-new-hallmarks-of-aging/ https://www.lifespan.io/news/researchers-propose-five-new-ha... Aging is complicated. Stuff like extracellular cross-linking of collagen through glycation cannot be reduced to genetic/epigenetic changes, and yet is obviously a huge problem for aged organisms.

inglor_cz 3y ago

"Aging is just the acclimation of error in genes as microscopic write errors accumulate in successive cell epochs." I don't think there is a scientific consensus on this particular mechanism as a root of aging. There is a lot of stuff happening along like epigenetic aging, accumulation of various toxins and seemingly pre-programmed atrophy of immune system in mammals. The only de-aging experiment that demonstrated some positive results in humans didn't touch genes at all. It was the TRIIM and TRIIM-X trial which attempted to rejuvenate the thymus and thus reinvigorate immunity. The subjects exhibit a lot of changes consistent with being a bit younger (a few years).

RelativeDelta 3y ago
I am unfamiliar with "epigenetic aging". Are you talking about methylation causing worse performance in one arena or another? Immune atrophy and toxic accumulation I would read as being the terminal effects of decreased functionality as a result of error accumulation, no?
- inglor_cz 3y ago
  The following page is written in a reasonably readable prose and lists all the currently accepted hallmarks of aging. Genomic instability is on the list, but many other things beside it. https://www.lifespan.io/topic/why-we-age/ https://www.lifespan.io/topic/why-we-age/ But there has been recent talk about adding five more: https://www.lifespan.io/news/researchers-propose-five-new-hallmarks-of-aging/ https://www.lifespan.io/news/researchers-propose-five-new-ha... Aging is complicated. Stuff like extracellular cross-linking of collagen through glycation cannot be reduced to genetic/epigenetic changes, and yet is obviously a huge problem for aged organisms.