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Sadly unlikely. Excess Retinol concentrations do not reduce the rate of base transcription error, nor do they prevent passive oxidative stress. What they do is

Sadly unlikely. Excess Retinol concentrations do not reduce the rate of base transcription error, nor do they prevent passive oxidative stress. What they do is preempt extra-environmental stress and the resultant write error. This is less protective and more avoidive. IE, if you have less Retinol then you are genetically optimized for you will accrue slightly more oxidative stress as a result of your deficiency. Supplements can prevent this particular stress by alleviating deficiency, but they can't reduce it beyond whatever your base rate is.

qwerty456127 3y ago
Do I get it right you still better have slightly elevated retinol when you get exposed to excessive environmental radiation (UV or whatever, e.g. go surfing in summer in Australia or take an overseas flight) yet avoid having too much of it in other cases?
- RelativeDelta 3y ago
  Exactly correct, but perhaps not in the way you think. Having excess retinol does not offer 'protection' in the literal sense. It does not shield your DNA as it replicates to replace the cells that died at the elevated rate of death due to UV exposure. Rather, retinol is rare (% of bodymass) and is a key component of the chain of cell duplication. Having excess retinol available means your processes won't 'run out' of it when they need it. This protects from the biological equivalent of 'cutting corners' in manufacturing and THIS is how it reduces transcription error. It's preventative by way of avoiding a deprivation. If you are anticipating any excess cell death for any reason, it is better to have a slight oversupply of retinol as well as a variety of other antioxidants. The benefits are (literally) microscopic but are cumulative over a lifespan. Think of it a bit like brushing your teeth. You're not rebuilding enamel, you're preventing it's loss.

qwerty456127 3y ago

Do I get it right you still better have slightly elevated retinol when you get exposed to excessive environmental radiation (UV or whatever, e.g. go surfing in summer in Australia or take an overseas flight) yet avoid having too much of it in other cases?

RelativeDelta 3y ago
Exactly correct, but perhaps not in the way you think. Having excess retinol does not offer 'protection' in the literal sense. It does not shield your DNA as it replicates to replace the cells that died at the elevated rate of death due to UV exposure. Rather, retinol is rare (% of bodymass) and is a key component of the chain of cell duplication. Having excess retinol available means your processes won't 'run out' of it when they need it. This protects from the biological equivalent of 'cutting corners' in manufacturing and THIS is how it reduces transcription error. It's preventative by way of avoiding a deprivation. If you are anticipating any excess cell death for any reason, it is better to have a slight oversupply of retinol as well as a variety of other antioxidants. The benefits are (literally) microscopic but are cumulative over a lifespan. Think of it a bit like brushing your teeth. You're not rebuilding enamel, you're preventing it's loss.