So not everything has a perfect linear dose response relationship especially in the body when there are multiple feedback loops that may make things better or w

So not everything has a perfect linear dose response relationship especially in the body when there are multiple feedback loops that may make things better or worse Then there is the liver whose job is to filter out said toxins. It might not be able to do it's job if the concentration is 1000x but at 1x it should be fine(assuming the liver can recognize and clear the toxin in the first place) You are right that we cannot reliably detect an increase in 1% risk but if the initial overall risk was just 0.5% does that increase even meaningfully contribute to anything?