IDO2 is stimulated during any infection but ongoing IDO2 expression could come from an iron deficiency. Iron is the cofactor for TPH1 and TPH2 which turns trypt

IDO2 is stimulated during any infection but ongoing IDO2 expression could come from an iron deficiency. Iron is the cofactor for TPH1 and TPH2 which turns tryptophan into serotonin. If that is not working the tryptophan will be turned into kynurenine by IDO1 and IDO2. https://www.mdpi.com/ijms/ijms-22-11714/article_deploy/html/images/ijms-22-11714-g001.png https://www.mdpi.com/ijms/ijms-22-11714/article_deploy/html/... Iron deficiency has been a common feature of LC for a while: https://timesofindia.indiatimes.com/life-style/health-fitness/health-news/is-iron-deficiency-an-after-effect-of-covid-infection-experts-answer-shed-light-on-the-signs-sources-and-supplementation/articleshow/92818880.cms https://timesofindia.indiatimes.com/life-style/health-fitnes...