> unless you get a low-acetogenin variety, eating them more than once in a while has health impacts, possibly a Parkinson's-like syndrome. Although acetogenins

> unless you get a low-acetogenin variety, eating them more than once in a while has health impacts, possibly a Parkinson's-like syndrome. Although acetogenins are very neurotoxic, they also have a fairly low bioavailability when the ripe fruits are eaten out of hand.[1] If you stick to eating only one or two fruits per day for the few weeks they're in season, you're unlikely to develop progressive supranuclear palsy. It's really if you're doing things to increase the bioavailability, like brewing the leaves into tea, cooking the fruit with fats, infusing the fruit into alcohol, etc. that you're more likely to run into issues. In the 400+ years of people eating the fruit in the United States, there is exactly one death associated with pawpaws, and that happened to an orchardist who had been eating the fruit for 30 years straight. Had they been aware that their PSP symptoms were being caused by pawpaw consumption, they could have stopped eating the fruit after 15 years and likely would have been fine. Keep in mind also that pawpaw consumption likely also reduces your risk of cancer, and since you're much more likely to get cancer than PSP, moderate pawpaw consumption is almost certainly a net positive for your health. There is also some new research that's come out within the last few weeks suggesting that metformin (also thought to be a mitochondrial complex I inhibitor) might reduce your risk of covid, so perhaps the fruit even has that going for it as well. Regardless, given that you can talk with plenty of folks who have eating 2,500+ over their lifetimes who don't seem to be having any ill effects, the average person probably doesn't have a whole lot to worry about by eating a handful of pounds of fruit per year. Also FWIW, here is a video I made last year showing my trees: https://www.youtube.com/watch?v=buJruAx0osg https://www.youtube.com/watch?v=buJruAx0osg And if you want more pawpaw content, Timothy Lane (Ockoo Farm) has the best YouTube channel on them right now: https://www.youtube.com/@abyssquick/videos https://www.youtube.com/@abyssquick/videos [1] Timothy Lane claims the bioavailability of the different acetogenins generally ranges from 1 - 5%, which seems about right although I have not fact checked this extensively myself.