3 ms·
It's probably not COVID hiding in the tissues? I wonder whether injection of genes by the virii result in altered DNA producing broken proteins. Is 23andMe data
by tomrod 3y ago
It's probably not COVID hiding in the tissues? I wonder whether injection of genes by the virii result in altered DNA producing broken proteins. Is 23andMe data of sufficient quality to test altered DNA?
- pja 3y ago23andme looks for specific single nucleotide polymorphisms (SNPs) so it’s completely unsuitable for looking for this kind of DNA alteration that could be anywhere in the genome.
- tomrod 3y agoThank you for the correction. How would you look for DNA alteration, generally?
- mnw21cam 3y agoWhole genome sequencing of some kind, preferably one of the newfangled long-read technologies such as Oxford Nanopore or Pacbio, would be best for looking for novel insertions into the genome. However, this is likely to be a fool's errand in this case, because this kind of sequencing normally assumes that we can take a sample of many cells from the body, and that all those cells have the exact same DNA changes. If you have a mutation that is induced in a parent or the single-figure-cell stage of embryo development then that will be true, but for DNA modification by a virus in an adult it will not be. Each cell will have a different insertion. Now, there are some techniques that can sequence the DNA from a single cell, but they don't give quite as good quality data, and because you'd be wanting to sample a good number of cells to see what the distribution of insertions is, it will likely also be very expensive.
- francisofascii 3y ago> It's probably not COVID hiding in the tissues? It totally could be. Viral persistence is a strong suspect. HIV hides in "sanctuary" tissues. Other viruses and bacteria probably can evade the immune system in certain types of tissue.