> This tiny little caveat is the entire point of my comment. Happy to converse about other stuff, but it's a tangential topic at best. Renshaw appears to be su

> This tiny little caveat is the entire point of my comment. Happy to converse about other stuff, but it's a tangential topic at best. Renshaw appears to be suggesting/hypothesizing that there is some universal "low O2" effect that leads to higher rates of suicide. I'm saying that this seems unlikely, given that in fully adapted individuals, the cellular environment does not experience low O2. Of course, in non-fully adapted individuals (either because they are still adapting, or because genetic/physiological factors prevent it), this would not be the case. But that still says that there's no "general" low-O2 mechanism that is affecting anyone who lives at altitude. It only suggests that there maybe a low-O2 mechanism that affects some individuals. Whether there is a correlation between suicide rates and altitude adaptation doesn't appear to be easily established.