5 ms·

(in mice)

Nowado 3y ago
It bothers me way less when it's not a medical treatment research.
insanitybit 3y ago
My naive perspective is that the foundational properties of the brain are probably really similar between mice and humans. For example, we have put human brain cells into rats and the brain cells have done... something. The chemistry is probably different in a bunch of ways "rats evolved to use this hormone to feel X, we use it to tell us Y" or some other such thing, but structurally I'd imagine that neurons function similarly. Anyone know more?
- convolvatron 3y ago
  even if there are structural differences, just the fact that we can establish a loose isomorphism between our knowledge about computational models and the cognitive processes of any living creature seems like a really profound step forward for cognitive science if it holds up. there isn't any issue about clinical relevance
  - insanitybit 3y ago
    I agree
- chaxor 3y ago
  Lack of Wernicke's and semantic representation similarity is a big difference for one
SubiculumCode 3y ago
There are some important differences between mice and human hippocampi, including different long range connections...however the overall patterns of organization across the hippocampal subfields e.g. heavy recurancy in CA3, sparse separation of signals in dentate gyrus, etc...these are very similar in structure and response patterns between species. ..gotta love the spiking data in human epilepsy patients
xjay 3y ago
2020-12: Some research done with human subjects regarding how the brain reacts when we're reading code. > The researchers saw little to no response to code in the language regions of the brain. Instead, they found that the coding task mainly activated the so-called multiple demand network. This network, whose activity is spread throughout the frontal and parietal lobes of the brain, is typically recruited for tasks that require holding many pieces of information in mind at once, and is responsible for our ability to perform a wide variety of mental tasks. [1] [1] https://news.mit.edu/2020/brain-reading-computer-code-1215 https://news.mit.edu/2020/brain-reading-computer-code-1215

(in mice)

It bothers me way less when it's not a medical treatment research.

My naive perspective is that the foundational properties of the brain are probably really similar between mice and humans. For example, we have put human brain cells into rats and the brain cells have done... something. The chemistry is probably different in a bunch of ways "rats evolved to use this hormone to feel X, we use it to tell us Y" or some other such thing, but structurally I'd imagine that neurons function similarly. Anyone know more?

convolvatron 3y ago
even if there are structural differences, just the fact that we can establish a loose isomorphism between our knowledge about computational models and the cognitive processes of any living creature seems like a really profound step forward for cognitive science if it holds up. there isn't any issue about clinical relevance
- insanitybit 3y ago
  I agree
chaxor 3y ago
Lack of Wernicke's and semantic representation similarity is a big difference for one

SubiculumCode 3y ago

There are some important differences between mice and human hippocampi, including different long range connections...however the overall patterns of organization across the hippocampal subfields e.g. heavy recurancy in CA3, sparse separation of signals in dentate gyrus, etc...these are very similar in structure and response patterns between species. ..gotta love the spiking data in human epilepsy patients

xjay 3y ago

2020-12: Some research done with human subjects regarding how the brain reacts when we're reading code. > The researchers saw little to no response to code in the language regions of the brain. Instead, they found that the coding task mainly activated the so-called multiple demand network. This network, whose activity is spread throughout the frontal and parietal lobes of the brain, is typically recruited for tasks that require holding many pieces of information in mind at once, and is responsible for our ability to perform a wide variety of mental tasks. [1] [1] https://news.mit.edu/2020/brain-reading-computer-code-1215 https://news.mit.edu/2020/brain-reading-computer-code-1215