3 ms·
I linked to Alex Washburne's criticism of Pekar (the "two lineages" paper) on biorxiv above, and I believe that's generally sound. (Note that he's got a differe
by tripletao 3y ago
I linked to Alex Washburne's criticism of Pekar (the "two lineages" paper) on biorxiv above, and I believe that's generally sound. (Note that he's got a different preprint alleging genomic evidence that SARS-CoV-2 was assembled using BsaI and BsmBI, which I believe is quite wrong.) That Twitter criticism is from a pseudonymous account, but it's clearly some kind of relevant academic.
Prominent journals have been unfortunately willing to publish low-quality work in support of natural zoonosis; I assume you don't think pangolins are the proximal host, but it took Nature more than a year to correct "Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins". David Relman published a note back in 2020, which doesn't say much but does refute the arguments of "Proximal origin":
https://www.pnas.org/doi/pdf/10.1073/pnas.2021133117 https://www.pnas.org/doi/pdf/10.1073/pnas.2021133117
There's no more recent summary that I'd recommend. The most notable development since then is perhaps the absence of notable developments; there's still very little evidence on either side, and these arguments often devolve into whether the PRC is covering up a research accident or covering up zoonotic origin. If SARS-CoV-2 did arise from a research accident, then the evidence confirming that may be an intelligence matter (like a leaked document) rather than new science. For example, the Sverdlovsk anthrax incident wasn't confirmed to be a lab accident until the fall of the Soviet Union.
Alina Chan's book is written for a popular audience, but well-referenced into the scientific literature. Jesse Bloom does excellent work, but his papers address particular narrow questions, nothing like a summary.