A lot of words to say: extremely low risk of overdose, some number of seizures and liver toxicity (unquantified in the article), and some risk of addiction (whi

A lot of words to say: extremely low risk of overdose, some number of seizures and liver toxicity (unquantified in the article), and some risk of addiction (which is probably unsurprising -- it is an opioid). To attempt to put some numbers on liver toxicity, this article[1] identified 11 cases of Drug-Induced Liver Injury from 2003-2019, with ~1.7 million Americans using kratom in 2019. To attempt to quantify seizures, we can look at this article[2] which claims 6.1% of reported kratom-associated (2312) or only-kratom (935) poisoning cases involved seizures. (About 141 individuals.) This is also against the same backdrop of ~1.7 million users. [1]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113016/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113016/ [2]: https://accpjournals.onlinelibrary.wiley.com/doi/abs/10.1002/phar.2280 https://accpjournals.onlinelibrary.wiley.com/doi/abs/10.1002...