does a nuke do the same damage in space, in a vacuum, with zero gravity, and no oxygen and other factors? would it do anything to a rock that's essentially as d

does a nuke do the same damage in space, in a vacuum, with zero gravity, and no oxygen and other factors? would it do anything to a rock that's essentially as dense as earths core adjusting for size? I think it'd be a cool test for them to do though.