Benzos attach to the benzodiazepine subunits on GABA receptors, and according to this paper[1], neurosteroids like this one also attach to similar subunits on G

Benzos attach to the benzodiazepine subunits on GABA receptors, and according to this paper[1], neurosteroids like this one also attach to similar subunits on GABA receptors[2]. Both act as positive allosteric modulators when activating their respective subunits on GABA receptors. This cited paper[3] also tested similar neurosteroids in progesterone receptor knockout mice and still found anxiolytic effects. [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139029 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139029 [2] See Figure 3A in [1] [3] https://pubmed.ncbi.nlm.nih.gov/15617723 https://pubmed.ncbi.nlm.nih.gov/15617723