4 ms·
why is this drug specific to PP depression? Would it work for typical, general depression in both sexes?
by fnord77 3y ago
why is this drug specific to PP depression? Would it work for typical, general depression in both sexes?
- mikeyouse 3y agoThe FDA evaluated evidence that the same drug would help treat major depressive disorder and found it lacking; https://www.fiercepharma.com/pharma/sage-biogens-postpartum-depression-approval-overshadowed-larger-depression-rejection https://www.fiercepharma.com/pharma/sage-biogens-postpartum-... > Alongside Friday’s approval, the partners also received a rejection for Zurzuvae in adults with major depressive disorder (MDD). The FDA told the partners their application didn’t provide “substantial evidence of effectiveness” and that additional studies would be needed. Sage and Biogen said they are reviewing possible next steps.
- esel2k 3y agoWhich immediately leads to layoffs: https://www.fiercebiotech.com/biotech/sage-braces-layoffs-pipeline-culls-shares-tank-wake-zuranolones-mdd-rejection https://www.fiercebiotech.com/biotech/sage-braces-layoffs-pi...
- psychphysic 3y agoIt's effects are likely best in short term depression related to anxiety and insomnia. PPD is just usually that type. The biggest factor is that this stuff is basically a Z-drug like Zolpidem/Ambien and so treatment is time limited. That makes it harder to use with MDD. At the same time it did not conduct comparative studies to TCA, SSRI or other modern antidepressants. "Treatment as usual" would likely be a short course of Z-drug. If a man went to the doctor and said I've lost my dad and I'm low, anxious and can't sleep one would imagine this would work. We don't know if it would work better than an antidepressant, or sedative because no comparison was done.