That is not a major issue by itself, just something to get used to. However, it becomes an issue if you have to use multiple designs. For example: Dell ships

That is not a major issue by itself, just something to get used to. However, it becomes an issue if you have to use multiple designs. For example: Dell ships all their laptops with ANSI-layouts, but Logitech does not ship ANSI-layouts to Europe at all. I ended up buying my Logitech keyboard on Ebay in the US, because I wanted my layouts to be identical.