There's always tradeoffs of course. How beneficial it will be depends on your use-case. I personally use Vim with an alternative layout for instance and have z

There's always tradeoffs of course. How beneficial it will be depends on your use-case. I personally use Vim with an alternative layout for instance and have zero problems. The standard ctrl-c/v/x/z is a consideration but it's perfectly fine to have then on another layer or under a combo. I really do get a huge benefit, as +90% of my time I type inside Vim with the keyboard. Slightly less efficient shortcuts for rarely used programs just doesn't bother me. For reference I use a 34 key keyboard using qmk.