4 ms·

1) Subset breakthrough here potentially related to cancer, we'll see how the peer review and evolution to becoming an available standard of care goes. City of

1) Subset breakthrough here potentially related to cancer, we'll see how the peer review and evolution to becoming an available standard of care goes. City of Hope scientists develop targeted chemotherapy able to kill all solid tumors in preclinical research https://www.eurekalert.org/news-releases/997141 https://www.eurekalert.org/news-releases/997141

MostlyStable 3y ago
I've heard elsewhere that "all solid tumors" should really more accurately be conveyed as "all solid tumors with a very specific mutation". It is, apparently, a very common mutation, but also not universal, even among solid tumors. Apparently. I'm not an expect, but it's what I have encountered elsewhere. Still great news! But not quite as revolutionary as the headline implies.
- JieJie 3y ago
  I was interested in learning more, based on your comment. Here's what I found out. City of Hope thinks they've found a chemotherapy that's "able to kill all solid tumors","in more than 70 cancer cell lines".[0] According to the National Cancer Institute[1], there are "more than 100 kinds of cancer". They're listed here: [2] Some of those cancers are soft tissue, so they aren't affected by this treatment. I didn't know what a cancer "line" was, so I looked it up. "Cancer cell lines are valuable in vitro model systems that are widely used in cancer research and drug discovery."[3] So, they're not cancers in people, but cell cultures they can test drugs on. This probably doesn't give you much more information than you already have, based on what you heard elsewhere, but I learned enough to figure maybe it would help someone else, too. Whether this'll work in people, I guess we'll find out when they start the Phase 1 clinical trial. If you, or someone you know think you might benefit from this, there is a link to sign up for Phase 1 trials.[0] It appears to have worked in pre-clinical trials, so they have tested this to make sure it doesn't kill people outright, the same way it does cancer cells.[4] [0]https://www.cityofhope.org/city-hope-scientists-develop-targeted-chemotherapy-able-kill-all-solid-tumors-preclinical-research https://www.cityofhope.org/city-hope-scientists-develop-targ... [1]https://www.cancer.gov/about-cancer/understanding/what-is-cancer https://www.cancer.gov/about-cancer/understanding/what-is-ca... [2]https://www.cancer.gov/types https://www.cancer.gov/types [3]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721418/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721418/ [4]https://xkcd.com/1217/ https://xkcd.com/1217/
isaacfung 3y ago
A few weeks ago, there was news that some Harvard MIT researchers had discovered a chemical cocktail that can reverse aging. https://news.yahoo.com/harvard-mit-scientists-claim-chemical-174910645.html https://news.yahoo.com/harvard-mit-scientists-claim-chemical...
- iraqmtpizza 3y ago
  is heart damage considered aging? asking for the 1 in 35.

MostlyStable 3y ago

I've heard elsewhere that "all solid tumors" should really more accurately be conveyed as "all solid tumors with a very specific mutation". It is, apparently, a very common mutation, but also not universal, even among solid tumors. Apparently. I'm not an expect, but it's what I have encountered elsewhere. Still great news! But not quite as revolutionary as the headline implies.

JieJie 3y ago
I was interested in learning more, based on your comment. Here's what I found out. City of Hope thinks they've found a chemotherapy that's "able to kill all solid tumors","in more than 70 cancer cell lines".[0] According to the National Cancer Institute[1], there are "more than 100 kinds of cancer". They're listed here: [2] Some of those cancers are soft tissue, so they aren't affected by this treatment. I didn't know what a cancer "line" was, so I looked it up. "Cancer cell lines are valuable in vitro model systems that are widely used in cancer research and drug discovery."[3] So, they're not cancers in people, but cell cultures they can test drugs on. This probably doesn't give you much more information than you already have, based on what you heard elsewhere, but I learned enough to figure maybe it would help someone else, too. Whether this'll work in people, I guess we'll find out when they start the Phase 1 clinical trial. If you, or someone you know think you might benefit from this, there is a link to sign up for Phase 1 trials.[0] It appears to have worked in pre-clinical trials, so they have tested this to make sure it doesn't kill people outright, the same way it does cancer cells.[4] [0]https://www.cityofhope.org/city-hope-scientists-develop-targeted-chemotherapy-able-kill-all-solid-tumors-preclinical-research https://www.cityofhope.org/city-hope-scientists-develop-targ... [1]https://www.cancer.gov/about-cancer/understanding/what-is-cancer https://www.cancer.gov/about-cancer/understanding/what-is-ca... [2]https://www.cancer.gov/types https://www.cancer.gov/types [3]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721418/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721418/ [4]https://xkcd.com/1217/ https://xkcd.com/1217/

isaacfung 3y ago

A few weeks ago, there was news that some Harvard MIT researchers had discovered a chemical cocktail that can reverse aging. https://news.yahoo.com/harvard-mit-scientists-claim-chemical-174910645.html https://news.yahoo.com/harvard-mit-scientists-claim-chemical...

iraqmtpizza 3y ago
is heart damage considered aging? asking for the 1 in 35.