Can Guanfacine be taken pro re nata like stimulants? If so, how long is the duration on average? One reason I have never considered the blood pressure medicati

Can Guanfacine be taken pro re nata like stimulants? If so, how long is the duration on average? One reason I have never considered the blood pressure medications is because, and correct me if I am wrong, if one takes them too consistently for too long, then sudden cessation can be dangerous and/or deadly. > The non-stimulant medications are very good Define very good. From what I have gathered during my browsing of research papers of varying quality, it seems that that non-stimulant options are perhaps at the level of "better than nothing." If I remember correctly, those who do well on MPH tend to do better on Atomoxetine, but even then, it's no guarantee. I've also read plenty of anecdotal evidence from people using Atomoxetine, and it seems like a large majority either cannot even make it past a few weeks due to intolerable side-effects. Also, the wikipedia page for Atomoxetine is not very reassuring with the statement: A 2020 meta-analysis found that atomoxetine was associated with anorexia, weight loss, and hypertension, rating it as a "potentially least preferred agent based on safety" for treating ADHD. What I really want to see if more head-to-head drug trials with all these medications and non-pharmaceutical alternatives. For example, how much more effective on average are stimulants than non-stimulants? Are things like caffeine, nicotine, or both combined more effective than non-stimulants? What about compared to stimulants? All I can ever find is research supporting if a medication is successful in reducing symptoms compared to a placebo. I just want to see them all ranked against themselves. Of course, I understand individual experiences would vary wildly, but I do think there is a potential for some utility in this data.