To be clear, they’re asking about having scrolling on a mouse and trackpad act differently from each other. The System Preferences / System Settings ‘Natural Sc

To be clear, they’re asking about having scrolling on a mouse and trackpad act differently from each other. The System Preferences / System Settings ‘Natural Scrolling’ option affects both mouse and trackpad, even though they’re in different places, and without third-party software it’s not possible to do what the commenter is asking.