Killing cancer is very similar to killing weeds in agriculture, it's full of ̶r̶a̶n̶d̶o̶m̶ ̶m̶u̶t̶a̶t̶i̶o̶n̶ biodiversity that give it all sorts of potential.

Killing cancer is very similar to killing weeds in agriculture, it's full of ̶r̶a̶n̶d̶o̶m̶ ̶m̶u̶t̶a̶t̶i̶o̶n̶ biodiversity that give it all sorts of potential. People get mutated cells all the time in their lifetime, but those cells get cleaned up because those cells don't have the proper mutations or circumstances to hide from the immune system. It's rare enough to find a way kill an organism but leave a related one safe, like trying to target millet in tall fescue grown for seed, or targeting mites on honeybees. Usually it's actually just a small difference in tolerance between the two that you are exploiting. We are trying to kill a human within a human. So what happens is that even if you wipe out 99.999% of the problem, it means the remaining portion of the pest had a genetic mutation that gave it increased resistance. So that's what will reproduce and you can't just increase the rate and try again. You are now just trying to stunt growth. This is why cancer can be reduced below detection limits, only to have it re-emerge several months or years later and kill the patient because the treatment no longer could touch it. Monotherapies should never be utilized, because failure will eventually occur. Failure in agriculture only means herbicide resistant annual ryegrass or kochia, eventual economic damages, and regulation mandating cycling of modes of action. But Failure in cancer treatment means death and a family burdened by massive debt. It should be noted that "cancer survival rates" are defined as the percent of people who survive a disease such as cancer *for a specified amount of time*. And I've noticed that the rates that get thrown around tend to range from a several months to just a few years. If a doctor manages to keep you alive and suffering for 2 years and a day before the cancer kills you, your "treatment success" gets added to X survival % (over two years) I definitely welcome more tools to utilize, but there should always be some form of multi-therapy, a magic pill is a dangerous hope that doesn't understand the enemy. Incidentally, look up Hyperthermia Therapy, it's less well known but pretty neat. It takes advantage that cancer cells aren't as robust to survive denaturing to begin with due to generally being in a low oxygen/blood environment (which limits detection by the immune system), but also that they are forced to either die or reopen their previously closed membrane transport systems which will now release chemical signals that the immune system can see as a problem. It's usually combined with chemicals that prime the immune system for "alertness". While this method isn't immune to resistance, it's able to exploit the very thing that the cancer needed to hide and survive.