Because cells, not just cancer, will find new ways to get around pathway blocks. Also, it's predecessor, AOH1160, didn't work: https://pubmed.ncbi.nlm.nih.gov/

Because cells, not just cancer, will find new ways to get around pathway blocks. Also, it's predecessor, AOH1160, didn't work: https://pubmed.ncbi.nlm.nih.gov/29967249/ https://pubmed.ncbi.nlm.nih.gov/29967249/ https://news.ucr.edu/articles/2019/10/02/research-focus-small-molecule-can-help-fight-breast-cancer https://news.ucr.edu/articles/2019/10/02/research-focus-smal... This is a single pathway block, systemic chemotherapy, but it does sound interesting. It binds to the PCNA region, and blocks it from assisting in repairing damaged DNA and keeps cells from replicating. Chemotherapy does a good job, too, of stopping cell replication through a variety of methods. Yet cancer cells mutate and sometimes find away around it (called platinum resistance). The beauty of AOH1996, is that it metabolizes well and seems (in animals, human clinical trials underway) to have low side effects. Seems to work in dogs? We'll have to see how humans cope with this. Full article: https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00221-0 https://www.cell.com/cell-chemical-biology/fulltext/S2451-94...