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It’s not. It’s just a molecule that binds to one mutation on one protein, albeit a very important one. There are many types of cancer that don't involve mutatio
by bglazer 3y ago
It’s not. It’s just a molecule that binds to one mutation on one protein, albeit a very important one. There are many types of cancer that don't involve mutations of this particular protein.
That’s not a reason to lose hope, this is in fact a remarkable achievement. It’s part of a broader story in which humans are becoming more and more effective at building individual molecules that fit into precise grooves in proteins, changing their shape by distances measured in the width of a hydrogen atom.
I hope you can see how difficult this is. It’s the work of lifetimes now, but there is a constant march of improvement to the techniques for measuring protein binding, huge recent jumps in our understanding of protein folding (AlphaFold), and in our ability to synthesize molecules that bind to proteins. Most of that is the kind of technical work that doesn’t make headlines, but it compounds over time into discoveries like the one described in the article