3 ms·
Is it even possible to change your gut microbiome significantly without doing something extreme like a fecal transplant? Also, I'm guessing that after someone'
by kypro 3y ago
Is it even possible to change your gut microbiome significantly without doing something extreme like a fecal transplant?
Also, I'm guessing that after someone's brain has developed it's going to become much harder to change.
That said, I'd be asking the alternative question, can we use this to give people high-functioning autism?
- hammock 3y agoWhat’s extreme about a fecal transplant, aside from the ick factor? It doesn’t strike me as that different from taking a probiotic or a suppository
- kypro 3y agoDoesn't it require a surgical procedure? I meant it's extreme in contrast to something more mundane like diet augmentation.
- jakear 3y agoNot at all. You just swallow fecal matter. Usually in a pill.
- jamiek88 3y agoNo. You eat a shit pellet. That’s it. It’s mainly used with c diff people who have had their gut micro biome wiped out by treatment.
- Ygg2 3y agoNot really. Usually it's inserted in your colon. It's no more invasive than colonoscopy.
- nomel 3y agoCorrect. A colonoscopy is not a surgical procedure: https://mackinawsurgerycenter.com/colon-rectal/colorectal-cancer-screening-endoscopy-vs-colonoscopy/ https://mackinawsurgerycenter.com/colon-rectal/colorectal-ca... > Technically, a colonoscopy is a type of endoscopy. An endoscopy is a nonsurgical procedure
- Ygg2 3y agoThere is a pill form, but I'm wondering how will those bacteria survive the acid? Also it can be done via nasal/oral tube to the guts.
- nomel 3y ago> but I'm wondering how will those bacteria survive the acid? They don't release in the stomach [1]: > The oral capsule tested in this study was specifically designed to open and release its content at the end of human small intestine only. There are many pills that release at different points, and speeds, through the digestion. This is why some pills are labelled "do not cut". See enteric coating [2]. [1] At least the early ones didn't. I doubt there would be a point in putting fecal matter in the stomach. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918368/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7918368/ [2] https://en.wikipedia.org/wiki/Enteric_coating https://en.wikipedia.org/wiki/Enteric_coating
- deleted 3y ago[deleted]
- nomel 3y agohttps://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/fecal-transplant#:~:text=Fecal%20transplantation%20is%20usually%20performed,is%20deposited%20into%20the%20colon https://www.hopkinsmedicine.org/health/treatment-tests-and-t... > Fecal transplantation is usually performed by colonoscopy. A gastroenterologist guides the colonoscope through the entire length of the colon, and, as it is withdrawn, the solution containing donor feces is deposited into the colon. > Less commonly, the transplant is delivered through a tube inserted through the nose that reaches into the duodenum, the area where the stomach connects with the small intestine. This method does not require bowel prep, but is associated with a higher risk of side effects such as aspiration pneumonia. > Sometimes, FMT can be delivered by a capsule that you swallow or through an enema. tldr: tube inserted somewhere to deposit, pill, or enema.
- localplume 3y ago[dead]
- azinman2 3y agoWhat's extreme is that the FDA has generally made the practice illegal, according to my GI. Some people suffered fatal bacterial infections so they pulled back on the topic. There might be still some experiments but I guess right now its still considered risky.
- jt2190 3y agoMy layman’s understanding is that your immune system has an “strong opinion” about what bacteria it will tolerate, so simply introducing new bacteria generally does not make a permanent change to your gut biome. Even fecal transplant doesn’t really work for transforming the gut biome, as I understand it. (It can help reestablish bacteria that were lost due to medication or disease though.)