6 ms·
Cancer pill AOH1996 shows promise in annihilating all solid tumours
- dankle 3y agoAll solid tumors or all solid tumors with a specific mutation in PCNA? Big difference…
- elil17 3y agoMy reading is that they believe it works across all solid malignant tumors because malignant tumors necessarily upregulate PCNA (since it's critical to cell division). I think they are also saying that it is agnostic to the particular mutations that upregulated PCNA.
- deleted 3y ago[deleted]
- mebazaa 3y agothis is super AI-generated. paradoxically, the PR release might be a better link: https://www.prnewswire.com/news-releases/city-of-hope-scientists-develop-targeted-chemotherapy-able-to-kill-all-solid-tumors-in-preclinical-research-301888576.html https://www.prnewswire.com/news-releases/city-of-hope-scient...
- joefigura 3y agoAgreed, the author on the linked article is listed as an AI, and the article is just an AI mangling of the PR release. The PR release is directly from the group and the link ought to be changed. Edit - Here is the FDA record page for the relevant clinical trial: https://classic.clinicaltrials.gov/ct2/show/NCT05227326?titles=AOH1996&draw=2&rank=1 https://classic.clinicaltrials.gov/ct2/show/NCT05227326?titl... The press release says they've published a paper today, but doesn't link to it or say where it was published. So if anyone has journal access and can see or share the paper let us know. Edit2 - The paper is here: https://www.cell.com/cell-chemical-biology/pdfExtended/S2451-9456(23)00221-0 https://www.cell.com/cell-chemical-biology/pdfExtended/S2451...
- rcpt 3y agoThe pill that cures cancer is made from superconductors and designed by AI. Get it delivered by self driving car.
- postalrat 3y agoNow that reverse engineering alien technology is public knowledge they can finally start releasing this stuff.
- gwill 3y ago"Percentage of the article that is generated by AI: 63%" I appreciate the transparency, but just raises questions for me. What parts were generated by AI? What edits were made to correct the AI? Why did they feel AI was necessary?
- joefigura 3y agoThat article should be ignored and people ought to read the PR that the research group put out. https://www.prnewswire.com/news-releases/city-of-hope-scientists-develop-targeted-chemotherapy-able-to-kill-all-solid-tumors-in-preclinical-research-301888576.html https://www.prnewswire.com/news-releases/city-of-hope-scient... Edit: Or better yet, the paper https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00221-0#secsectitle0035 https://www.cell.com/cell-chemical-biology/fulltext/S2451-94...
- deleted 3y ago[deleted]
- apsec112 3y agoNormally I'd say IN MICE, but this appears to be in a Petri dish, not even in animals.
- gardenfelder 3y agoClinical trials on humans described here: https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/pcna-inhibitor-aoh1996?redirect=true https://www.cancer.gov/about-cancer/treatment/clinical-trial... Full paper on the drug here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279569/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279569/
- joefigura 3y agoThat is not the paper mentioned in the press release, that's a different paper on the drug published in 2018 by the same group. The current paper is here: https://www.cell.com/cell-chemical-biology/pdfExtended/S2451-9456(23)00221-0 https://www.cell.com/cell-chemical-biology/pdfExtended/S2451...
- TaupeRanger 3y agoFlagged. This is a source-free article created by an "AI editor" on a fluff website. Please stop upvoting it. The drug is still in Phase I trials and has NOT released any data on the patients yet.
- return_to_monke 3y agoLk-99 and now this. God the hopium is on insane doses right now