I've never given much thought to this, but I use Windows at work and Linux at home and haven't clocked the difference. At work I mapped the up-and-right thumb b

I've never given much thought to this, but I use Windows at work and Linux at home and haven't clocked the difference. At work I mapped the up-and-right thumb button on my mouse to "Enter" and the down-and-left button to "Esc", which I find very convenient specifically for CAD. I got my mouse replaced when the left click button went bad and took the old mouse home and replaced the switch. I set up the same mapping, and I haven't noticed any dissonance. The biggest confusion I notice is scroll-to-zoom, where you have a 50% chance of using up to zoom in down to zoom out and 50% of the other way. I haven't found a good way to guess which applications will do which (on my CAD workstation I have one of two programs set to inverted scroll, and I won't remember which one it is unless I run into a new installation).