This is incorrect and dangerous advice. Ethanol metabolism consumes S-glutathione, of which you have limited stores, and which is resynthesized over time. Ace

This is incorrect and dangerous advice. Ethanol metabolism consumes S-glutathione, of which you have limited stores, and which is resynthesized over time. Acetaminophen is metabolized to a toxic metabolite, NAPQI, which can be eliminated by glutathione conjugation via gluthione-S-transferases. When glutathione stores are depleted, for example due to alcohol consumption or acetaminophen overdose, NAPQI builds up and causes direct liver injury and cellular death: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836803/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836803/ As it relates to alcohol, the combination is also dangerous because alcohol's metabolic byproduct acetaldehyde also builds up and causes cellular damage in the absence of sufficient glutathione (which soliloquizes it for urinary excretion)