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Genetic differences can alter caffeine metabolism significantly, reducing half-life by up to 80% (which has a huge impact since it’s typically 5-6 half-lives to
by refurb 3y ago
Genetic differences can alter caffeine metabolism significantly, reducing half-life by up to 80% (which has a huge impact since it’s typically 5-6 half-lives to “flush” a drug out of your system).
Basically it may take some individuals 48 hours to metabolize all caffeine while others may do it in 10 hours.
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800839 https://jamanetwork.com/journals/jamanetworkopen/fullarticle...
- coreyh14444 3y agoI'm in this camp and it sucks. If I have a full size cup of coffee at 5am, my sleep will suffer. Otherwise fit, healthy dude in my 40s, but have the caffeine tolerance of a toddler.
- sschueller 3y agoWorking out seems to also affect this. The days I workout I can "tolerate" more than when not.
- red-iron-pine 3y agosame. a hard workout beats me up and gets me sleeping like a baby. i'd imagine the blood pumping, sweat, lots of water intake, and boost to metabolism probably doesn't hurt either.